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Integrin alpha V beta 6

概要

Name:Integrin alpha-V/beta-6
Target Synonym:
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:6
Lastest Research Phase:Phase 3 Clinical

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生物活性データの一部

CHEK-ATP125-Cell-based assay
 Integrin alpha V beta 6 FACS

Expression analysis of human Integrin alpha V on HEK293/Human Integrin alpha V beta 6 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human Integrin alpha V beta 6 Stable Cell Line or negative control cell using anti-human Integrin alpha V antibody followed by staining with FITC anti-mouse IgG Antibody.

CHEK-ATP125-Cell-based assay
 Integrin alpha V beta 6 FACS

Expression analysis of human Integrin beta 6 on HEK293/Human Integrin alpha V beta 6 Stable Cell Line by FACS.
Cell surface staining was performed on HEK293/Human Integrin alpha V beta 6 Stable Cell Line or negative control cell using anti-human Integrin beta 6 antibody followed by staining with PE anti-human IgG Fc Antibody.

IT6-C52W9-SPR
 Integrin alpha V beta 6 SPR

Fibronectin fragment, premium grade (Cat. No. FIN-H5113) immobilized on CM5 Chip can bind Cynomolgus ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT6-C52W9) with an affinity constant of 0.946 µM as determined in a SPR assay (Biacore 8K) (Routinely tested).

IT6-H52E1-SPR
 Integrin alpha V beta 6 SPR

Fibronectin fragment, premium grade (Cat. No. FIN-H5113) immobilized on CM5 Chip can bind Human ITGAV&ITGB6 Heterodimer Protein, His Tag&Tag Free (Cat. No. IT6-H52E1) with an affinity constant of 1.23 µM as determined in a SPR assay (Biacore 8K) (Routinely tested).

カスタマーレビュー

Synonym Name

Integrin alpha V beta 6,ITGAV&ITGB6

Background

Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency‑associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.

Clinical and Translational Updates

臨床試験情報

Name Research Code Research Phase Company Indications Clinical Trials
BG-00011 hu3G9; STX-100; BG-00011 Biogen Inc Details
IDL-2965 IDL-2965 Phase 2 Clinical Indalo Therapeutics Inc Non-alcoholic Fatty Liver Disease; Idiopathic Pulmonary Fibrosis Details
[18F]FP-R01-MG [18F]FP-R01-MG; [18F]FP-R01-MG-F2 Phase 1 Clinical Pliant Therapeutics Inc, Stanford University, Chinese Academy Of Medical Science & Peking Union Medical College Idiopathic Pulmonary Fibrosis; Coronavirus Disease 2019 (COVID-19); Pancreatic Neoplasms; Cholangitis, Sclerosing; Brain metastases; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung Details
PLN-74809 PLN-74809 Phase 2 Clinical Pliant Therapeutics Inc Idiopathic Pulmonary Fibrosis; Coronavirus Disease 2019 (COVID-19); Respiratory Distress Syndrome, Adult; Cholangitis, Sclerosing Details
OTT-166 OTT-166 Phase 2 Clinical OcuTerra Therapeutics Inc Diabetic Retinopathy Details

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